Liquid Biopsy (OncoSELECT Kit)

Targeted Liquid Biopsy to Support Your Clinical Decisions

The OncoSELECT Kit is OncoDNA’s first decentralised RUO (Research Use Only) solution for liquid biopsies , it benefits from having been used in a routine centralised setting for many years ensuring that laboratories can leverage OncoDNA’s extensive expertise locally. The OncoSELECT Kit encompasses more than 70 genes, including pertinent HRR genes, reporting genomic alterations and enabling the identification of MSI and CNV.

When a solid biopsy is impossible or unavailable, the OncoSELECT Kit is recommended as a non-invasive solution to detect ctDNA in the blood of cancer patients. Underpinning the kit is Twist Bioscience reagents, and OncoDNA’s data analysis and clinical interpretation tool, OncoKDMTM. Using the data gathered in OncoKDMTM, molecular biologists can create a report that will ensure oncologists increase patient access to precision oncology.

10 years of knowledge that matters

Since 2013, OncoDNA has performed more than 35,000 tests, enabling us to build a comprehensive database (OncoKDO®) comprising 4,5 million variants across 22,000 genes, along with information on 1,400 drugs and 9,000 clinical trials. This vast repository of information allows OncoDNA to provide our clients with the most accurate and up-to-date molecular profiling for personalized cancer treatment.

A unique capture method for high quality data with less sequencing

OncoSELECT® Kit uses a unique Twist Biosciences’ capture method allowing high coverage and uniformity with less DNA input and less sequencing needed.

An easy process automatization

Thanks to the compatibility with Illumina’s technology, the easy automation process simplifies tasks by continuing using the current tools without disturbing the automate routine activities and losing time in extra training and manipulations.

Compatible with Illumina Technology

OncoSELECT® Kit has been meticulously designed to seamlessly integrate Illumina’s cutting-edge sequencing platforms, ensuring a streamlined and efficient workflow. This singular compatibility empowers researchers to concentrate on their scientific goals, free from the burden of technical obstacles. By optimizing the compatibility of OncoSELECT® Kit, we strike the perfect balance between cost efficiency and constand precision, guaranteeing reliable results without compromising accuracy.

Achieving high-performance sequencing is now more accessible than ever, thanks to the OncoSELECT® Kit and Illumina sequencers. By utilizing these cutting-edge technologies, laboratories can process multiple samples per flow cell, as outlined in the Table above. This streamlined process allows faster and more efficient sequencing, resulting in more accurate data and better outcomes.

From sample preparation to clinical insights in just 5 days

OncoSELECT® Kit revolutionizes the diagnostic process by significantly reducing the timeline from DNA extraction to clinical and biological interpretation to just 5 days. This accelerated timeframe enables healthcare professionals to make faster decisions, resulting in enhanced patient care and improved outcomes.

Clear data insight and clinical interpretation

Easy sequencing files upload

After the sequencing, output files (FASTQ + Medata files) are uploaded

Easy sequencing files upload

After the sequencing, output files (Fastq + medata files) are uploaded on a secured storage to automatically launch a batch of samples.

Variants identification & annotation

Our BioIT pipeline performs the secondary analysis of genomic data

Variants identification & annotation

Our BioIT pipeline performs the secondary analysis of genomic data by aligning the data, identifying, annotating and classifying the variants, and cleaning the bias.

Data cross-referencing with our proprietary knowledge base

We use our proprietary knowledge base

Data cross-referencing with our proprietary knowledge base

We use our proprietary knowledge base OncoKDO to perform tertiary analysis by cross-referencing molecular data, resulting in the clinical interpretation of the data.

Clinical validation by scientific team

Our team of oncology experts reviews each report

Clinical validation by scientific team

Our team of oncology experts reviews each report before making it available on OncoKDM

OncoKDM® ’s comprehensive interpretation reports provide labs with eight essential assets to enhance the understanding of NGS data, including detailed annotations, a list of actionable variants, a list of therapies recommendation and a summary of relevant clinical trials.