OncoDEEP® : Our comprehensive cancer biomarker test

Comprehensive biomarker testing – also known as comprehensive genomic profiling or genomic cancer test or molecular diagnostic test – is a next-generation sequencing (NGS) approach that uses a single assay to detect relevant cancer biomarkers, alterations in genes that are known to drive cancer growth, as established in guidelines and clinical trials, for therapy guidance. OncoDEEP goes one step further by integrating tumor-specific biomarker analyses to maximize the clinical benefit for the patients.

Combining different biomarker analyses is the key to maximize the clinical benefit for the patients. A study demonstrated the clinical utility of integrating DNA, RNA and proteins in one single biomarker test. The trial was led on 1,057 advanced cancer patients in 30 countries on 4 continents that had already experienced treatment failure(s).

The OncoDEEP comprehensive biomarker test combines NGS with IHC testing to screen for genomic alterations in the DNA and RNA (BRCA mutation, KRAS mutation, EGFR mutations, etc), genomic signatures (tumor mutational burden, homologous recombination deficiency and microsatellite instability testing) and protein biomarkers of response to targeted therapies, immunotherapy, hormonal therapy and chemotherapy. The technology is robust and accurate, and the genes of the panel were carefully selected based on their biological and therapeutical relevance.

Analyses of RNA genes enable the identification of gene fusion and unusual splicing variants that are present in solid tumors and that may predict a patient’s sensivitity to targeted therapy or homorne therapy. An example is the targeted therapy “larotrectinib”. A pan-cancer drug that targets abnormal TRK gene proteins in patients with NTRK fusion cancer.

The OncoDEEP panel includes 20 RNA genes (e.g. NTRK gene, FGFR gene, BRAF gene) that are associated with personalized medicines. Those personalized medicines can be a targeted therapy, a hormonal therapy, or an oncology clinical trial that is currently recruiting. We do not make any distinction between solid tumor types and we run RNA sequencing for all patient cases, be they diagnosed with a breast cancer, ovarian cancer, NSCLC, prostate cancer or a glioblastoma to name a few.

Comprehensive biomarker testing is recommended for adults with stage 3 cancer or stage 4 cancer with solid tumors – such as metastatic breast cancer, stage 4 lung cancer, stage 3 colon cancer, metastatic prostate cancer, stage 4 ovarian cancer – or for children with brain cancer. In case of cancer of unknown primary (CUP cancer), OncoDEEP can help decipher the primary origin of the tumor and guide clinicians towards approved therapies or drugs currently in development in oncology clinical trials.

OncoDEEP can be used at diagnosis or at disease progression to identify biomarker-matched targeted therapies or biomarker-stratified clinical trials. It can also provide physicians with extra therapeutic guidance when chemotherapy does not work; when new biomarkers are required for second-line treatment; when cancer comes back; or when patients are diagnosed with highly aggressive cancer or a rare cancer type like a cancer of unknow primary.

Ordering a solution is very simple: Just log in to OncoSHARE and select the biomarker test(s) you are interested in. If you do not have a kit for the collection of the FFPE tissue sample, we will send you one.

For information regarding the price of our OncoDEEP® biomarker test in your respective country, please contact our sales team.